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Switching may be considered for several reasons, including: Inadequate weight loss results Side effect intolerance Changes in insurance coverage Plateauing on current medication Seeking stronger appetite suppression or satiety Most transitions involve cross-titration, gradually adjusting doses to minimize gastrointestinal side effects and support a smooth switch
The increase in risk was demonstrated in year 1 and persisted [see Clinical Studies (14.3)]
DOI:10.1111/1523-1747.ep12465218 [ Links ] 72
Metformin promotes osteogenic differentiation of adipose-derived stromal cells and exerts pro-osteogenic effect stimulating bone regeneration
Decreased sweating and increased body temperature (fever)
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