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Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
Nutrients 13:2814
Injectable semaglutide (Wegovy, Ozempic): Subcutaneous injection delivers drug directly into tissue Slow absorption from injection site into bloodstream Terminal half-life: 165 to 184 hours (approximately 7 days) Steady state reached after 4 to 5 weeks of weekly dosing Weekly dosing works because each injection adds to existing blood levels before previous dose is fully eliminated Oral semaglutide (Rybelsus): Absorption occurs in stomach via SNAC-mediated mechanism Peak plasma concentration at 1 hour Rapid distribution phase (1 to 6 hours) Terminal half-life is the same (7 days) once the drug is in the bloodstream, but the absorption phase is completely different Daily dosing is required because the absorption event itself is daily, not because the elimination is fast The confusion arises because half-life describes elimination, not absorption
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In the last 10 to 15 years, discoveries on certain gut peptides that influence insulin secretion related to meal ingestion, namely incretins, have opened up a new paradigm in the treatment of diabetes [4]
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