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Consider side effect profiles : Discuss tolerance for gastrointestinal symptoms versus risk of genitourinary infections
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Thus, in mice, significant antihyperglycaemic effects of DPP-4 inhibition are still apparent in animals lacking the GLP-1 receptor (43), while in clinical studies, GLP-1 receptor antagonism (using exendin 9-39) eliminates only approximately half of the glucose-lowering effect in patients with T2DM treated with DPP-4 inhibitors (44, 45)
Read here for more information on the class of drugs known as GLP-1 agonists
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