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You should also seek care if you experience any of the following on tirzepatide: Signs of pancreatitis, such as severe abdominal pain Stomach pain that radiates to your back Signs of an allergic reaction, such as swelling of the throat and trouble swallowing Other GI symptoms that wont go away, such as vomiting, diarrhea , and upset stomach Depending on your situation, your healthcare provider might recommend: Lowering your dose

The FDA has noted that lack of therapeutic effect is "probably the biggest thing" clinicians observe with grey market products

Nauck MA, Firsching M, Engelhardt M, Scholz M, Schmiegel W, Harders A

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Beyond Potency: The Safety Hazards of Visible Abnormalities The presence of visible particles is particularly concerning because this may: Represent peptide aggregation Microbial contamination Interaction between the drug and container components Even small particles that settle at the bottom of the vial warrant discarding the medication