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these immunosuppressive effects are important in ensuring successful pregnancies by preventing fetal rejection (128, 139142)

RACKER E (1953)

Activated M1 macrophages generate high levels of ROS through inducible nitric oxide synthase (iNOS) and NADPH oxidases, while secreting cytokines such as TNF- and IL-1 that exacerbate mitochondrial membrane potential loss and activate inflammasome pathways [49]

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And research backs this up, with one study even finding that 500 mg of carnosine once per day helped enhance exercise performance