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Tumors and other injuries to the pituitary gland can result in a lack of sufficient HGH production

Within the L cells the proglucagon gene is transcribed into proglucagon, which is cleaved by enzymes to form GLP-1

MC1R is the primary melanocortin receptor governing skin pigmentation and expressed on melanocytes, keratinocytes, fibroblasts, and immune cells in the skin , whose activation by -MSH drives melanin synthesis, melanocyte dendritic extension, photoprotective eumelanin production, and anti-inflammatory signalling in response to ultraviolet radiation

Gromer S, Arscott LD, Williams CH Jr, Schirmer RH, Becker K (1998) Human placenta thioredoxin reductase

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