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2 Slowing of gastric emptying By slowing the rate at which food moves from the stomach to the small intestine, cagrilintide extends the sensation of fullness after meals and moderates the speed at which glucose enters the bloodstream

The Phase 2 combination trial in type 2 diabetes reported that, by its 32-week endpoint, the cagrilintide-plus-semaglutide arm reached 15.6% mean weight loss versus 8.1% for cagrilintide alone and 5.1% for semaglutide alone with the combination curve already diverging upward through the early months (Frias et al., 2023)