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Currently licensed weight management treatments in the UK include orlistat (available on prescription and over the counter), and the GLP-1 receptor agonist semaglutide (Wegovy), which received MHRA approval for chronic weight management in adults and is supported by NICE technology appraisal TA875
In a head-to-head comparison, tirzepatide users lost an average of about 20% of body weight over 72 weeks, versus roughly 15% with semaglutide (source: NEJM)
Starting at a low dose reduces the risk of gastrointestinal side effects such as nausea, vomiting, and stomach discomfort
-Fos NMDA- NMDA- [89]
All of these options should only be used under the guidance and supervision of a qualified healthcare professional like Dr
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