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Early pharmacology studies characterized it as a ghrelin-receptor agonist with selective growth-hormone-releasing activity in the experimental systems studied

BPC-157 and standard angiogenic growth factors: gastrointestinal tract healing and lessons from tendon, ligament, muscle and bone healing

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The Hostynek and Maibach group at UCSF measured exactly this in 2011: human skin permeation of GHK-Cu as a function of skin layer, with the result that the peptide accumulates in the upper stratum corneum but does not pass through to viable epidermis or dermis in any meaningful quantity 4

It's worth noting that GI symptoms, including potential reflux, often attenuate over time as the body adjusts to treatment, particularly after completing the dose titration period