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The SURMOUNT-5 trial showed tirzepatide produces about 47% more weight loss than semaglutide on average, which is 20.2% versus 13.7% body weight reduction over 72 weeks

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Some people also find that pressing firmly near (but not at) the injection site with a finger for a few seconds before inserting the needle provides competing sensory input that reduces pain perception

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Tirzepatide is available under the names Mounjaro and Zepbound in the U.S.: Mounjaro FDAapproved since May 2022 for type 2 diabetes management

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Any advice given is from the manufacturer and acts as a guide only

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