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This superiority was confirmed in a large retrospective study of 140,308 T2D patients, where tirzepatide showed significantly lower risks of all-cause mortality, MACE, and MAKE compared to GLP-1 RAs 8

Initially approved for glycemic control in type 2 diabetes mellitus, their clinical application has expanded into obesity management, cardiovascular risk reduction, and metabolic syndrome modulation

Conflict of Interests Statement:The authors do not declare any conflicts of interests for this study

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Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage