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Preclinical studies have examined the peptide in models of gastrointestinal injury, epithelial disruption, and anastomosis healing where researchers analyze mucosal architecture, vascular integrity, and epithelial continuity following tissue damage [1]
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TB-500 is a 43-amino-acid synthetic fragment of thymosin beta-4, a small protein originally isolated from calf thymus tissue
The molecule was advanced into clinical development by the Croatian pharmaceutical company Pliva under the designations PL-10, PLD-116, and PL 14736 for inflammatory bowel disease research
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