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Ozempic and Wegovy (and Rybelsus, which is oral semaglutide) are GLP-1 receptor agonists (glucagon-like peptide-1 receptor agonists, commonly referred to as GLP-1s) and are the only FDA-approved drugs that contain the active ingredient semaglutide

The single-receptor profile makes Semaglutide the cleanest research reference for isolating pure GLP-1R signalling effects

Pancreatic cancer Early reports raised concerns that GLP-1 drugs, including semaglutide, might increase the risk of pancreatic cancer because some patients experienced pancreatitis (inflammation of the pancreas)