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For constipation management, increasing soluble fibre gradually (such as ispaghula/psyllium) is recommended by NICE guidance for IBS, while excessive insoluble fibre should generally be avoided as it may worsen symptoms

All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB)

A randomized trial of Icatibant in ACE-Inhibitor-Induced Angioedema

Pulmonary aspiration risk: rare but severe Of the 982 GLP-1RA-linked IGE cases, 13 (1.3%) led to pulmonary aspiration

The lack of standardized methods to evaluate total antioxidant capacity and the oxidation state and the use of inadequate antioxidants and/or improper concentrations of antioxidants lead to failure of numerous clinical trials directed to prevent or mitigate progression of atherosclerosis (230233)