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Beyond energy production, NAD+ also supports several important biological processes including: Activating longevity pathways called sirtuins Supporting DNA repair mechanisms Improving mitochondrial function Helping regulate metabolic health Unfortunately, NAD+ levels naturally decline as we age

PINK1-mediated Drp1 S616 phosphorylation modulates synaptic development and plasticity via promoting mitochondrial fission

Some chalk this up as their skin getting worse before it gets better, but whats really going on