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The older drugs have been successfully tested as a way to maintain weight after bariatric surgery, but they havent been studied among people coming off of GLP-1s, David Cummings, a professor at the University of Washington, told me

For example, tirzepatide, marketed as Mounjaro for diabetes and Zepbound for weight loss, is a dual agonist, combining GLP1 and GIP receptor activity

In a Phase I clinical trial, the drug demonstrated positive preliminary effects, achieving an average weight reduction of over 8% after four weeks of treatment in an overweight or obese population, indicating its strong potential for weight loss

Referral to an endocrinologist or obesity medicine specialist may be appropriate in these cases

Thus, following the example of cancer, drug therapy could precede bariatric surgery in order to render it safer and more feasible, but could also follow if the results are not satisfactory