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The same result was obtained in the active controlled studies (WMD = 2.37 kg, 95% CI 0.30 to 4.44, P = 0.02, I 2 = 0%), while there is no statistically significant distinction observed between the two subgroups ( P = 0.55) (Additional file 2: Fig

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To date, the PIONEER REAL studies in Canada, Switzerland, the Netherlands and Japan have been completed

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Age verification (minimum 18 years) is required for all purchasers and institutions compliance must be confirmed before proceeding with orders.Research institutions must ensure that all personnel handling these compounds understand the research-only limitations and maintain proper documentation of compound use

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