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More serious but less common adverse effects include: Pancreatitis : Patients should seek immediate medical attention if experiencing severe, persistent abdominal pain radiating to the back Gallbladder disease : Rapid weight loss can increase the risk of gallstones Hypoglycaemia : Particularly when used alongside other diabetes medications such as sulphonylureas or insulin Diabetic retinopathy complications : Rapid improvement in blood glucose control may temporarily worsen retinopathy in susceptible individuals Acute kidney injury : Usually in the context of dehydration from vomiting or diarrhoea Animal studies have shown an increased incidence of thyroid C-cell tumours with semaglutide, though the human relevance of this finding is unknown

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The researchers note that people previously treated with tirzepatide generally lost more total weight initially, which may partly explain the larger rebound

Full liquid phase: A smooth protein gelatin may be an option if your plan allows protein powder and you tolerate it well