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24 Cosmetics/Beauty and Wellness Industry: The psychological impact of the change could have a similar impact on the cosmetic/beauty industry, with a Piper Sandler analyst recently highlighting that the broader awareness for appearance could be a tailwind. 25 5: Reduction in Average Weight A reduction in average weight across the population could also have widespread impact across several industries

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Translationally, the apelinAPJ system illustrates a broader challenge for metabolic peptides with cardiovascular overlap: indication-specific development is likely required