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GCL is composed of a catalytic (GCLC, Mr ~73 kDa) and a modifier (GCLM, Mr ~31 kDa) subunit [32] (summarized in Fig

They establish biological mechanisms in controlled settings but do not constitute proof of specific human outcomes

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[1] Retatrutide: What the Evidence Actually Shows Retatrutides pivotal obesity dataset is a Phase 2, double-blind, randomised, placebo-controlled trial in adults with obesity (or overweight plus a weight-related condition), testing once-weekly doses up to 12 mg over 48 weeks