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Acral lentiginous melanoma (ALM) can be difficult to diagnosis and has a lower response rate to available therapies for cutaneous melanoma, such as immune checkpoint inhibitors, but survival in the metastatic setting is second only to pure cutaneous melanoma

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Ethics declarations Ethics Approval The experimental design for animal groups adhered to the technique authorized by the National Research Centres Institutional Animal Ethics Committee in Dokki, Giza, Egypt

[PMID: 8657328] PubMed record related to this compound for laboratory literature review

The Blood Service Biobank personnel are acknowledged for organizing research project-specific sample collection in blood donation activities and Aurea biobank thanked for samples of diseased individuals