Iepsen EW, Lundgren JR, Hartmann B, Pedersen O, Hansen T, Jorgensen NR, Jensen JE, Holst JJ, Madsbad S, Torekov SS
Antizyme 3 isoform 1 is the longest protein encoded by the OAZ3 gene and the translation of this form of the enzyme begins from a CUG codon and not an AUG codon
These receptors likely collaborate with GLP-1Rs in other brain regions, collectively mediating the anorectic and body weightlowering effects of liraglutide (9, 26, 49)
Its cardio-metabolic benefits offer a holistic approach to T2D management. Following these results, Novo Nordisk has submitted a label extension application for oral semaglutide to both the US FDA and the EMA, with regulatory decisions expected later in 2025
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