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On the other hand, certain stressors (e.g., uremic toxins) activate the AHRHsp90MDM2 axis, promoting VDR ubiquitination and degradation (18), which aggravates local inflammation

Some have struggled with high costs or limited insurance coverage, which can put treatment out of reach

The trial did have a conflict of interest in that it received support from a company that provides Setria, but it was also a randomized, double-blinded, and placebo-controlled trial with sound methods

Bruno A, Pandolfo G, Crucitti M, Lorusso S, Zoccali RA, Muscatello MR

doi: 10.1016/j.amjmed.2014.04.017 144 AzzizRCarminaEChenZDunaifALavenJSLegroRSet al