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Additionally, there is an increase in RBC-MPs [413]

Dosage adjustments may be needed with changes in physical activity, changes in meal patterns (i.e., macronutrient content or timing of food intake), changes in renal or hepatic function or during acute illness to minimize the risk of hypoglycemia or hyperglycemia [see WARNINGS AND PRECAUTIONS and Use In Specific Populations ]

While numerous antioxidants demonstrate protective effects in cellular and animal models, the number of well-controlled human clinical trials remains limited