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Ask why they are recommending a non-standard schedule, what evidence supports it, and what the plan is to transition back to weekly dosing
Periodic acid-Schiff (PAS) staining was performed
Compared to endogenous GLP-1 and glucagon, retatrutide demonstrates lower potency at GLP-1 and glucagon receptors but substantially higher potency at the human GIP receptor a pharmacological profile deliberately engineered to balance efficacy with tolerability
Greene CRL, Blackbourn LAK, McGurnaghan SJ, Mercer SW, Smith DJ, Wild SH, et al
www.fda.gov/Drugs/DrugSafety/ 18
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