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The exocrine pancreas: biology, pathobiology and diseases , 2 nd edition, pp 219-252, 1993

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One potential mechanism is the Nrf2-ARE pathway, which induces a phase 2 detoxification response that promotes disruption of Nrf2-Keap protein interactions, translocation of Nrf2 to the nucleus, and regulation of target gene expression through the ARE, enhancing cellular defense against oxidative damage (Sharma et al., 2010)

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Moreover, the hyperhomocysteinemia associated with an increased cardiovascular risk is stronger in non-insulin-dependent diabetes mellitus than in normal subjects (Hoogeveen et al, 1998)