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The success of these lower-reactivity warheads, especially through rationally designed Targeted Covalent Inhibitors (TCIs), has driven a boom in covalent drug development

Clinical comparison of weight- and age-based strategy of dose administration in children receiving intravenous busulfan for hematopoietic stem cell transplantation

However, regulatory guidance states that when the ratio of the area under the concentration-time curve (AUC) of the victim drug with and without the perpetrator drug falls outside the range of 0.81.25, there is a potential risk of a clinically significant impact, necessitating further investigation

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Complementary strategies, such as modified nutrition and increased movement, enhance their effectiveness