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Lopez-Leon S, Wegman-Ostrosky T, Perelman C, Sepulveda R, Rebolledo PA, Cuapio A, et al
Glucagon-like peptide-1 (GLP-1) receptor agonists represent a class of medications originally developed for managing type 2 diabetes but increasingly recognised for their weight management properties
Body weight and BMI play a role in determining eligibility for weight management trials, with most retatrutide studies enrolling adults with a BMI of 30 kg/m or above, or 27 kg/m or above in the presence of weight-related comorbidities such as hypertension or dyslipidaemia
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The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans
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