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As Kannt & Pfenninger highlight in Frontiers in Physiology , maintaining NAD levels is a cornerstone of metabolic health, supporting mitochondrial function and improving resistance to metabolic stress (Kannt & Pfenninger, Frontiers in Physiology )

In the long term, treated patients survived for longer because of this, than did untreated patients

Neurological function depends heavily on adequate methylcobalamin for myelin sheath maintenance and neurotransmitter synthesis

Fish is also rich in B12 especially tuna, trout, and salmon

It depends on the health conditions being studied, the dosage, and individual factors