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These studies are earlier stage but reflect the breadth of conditions that share overlapping reward circuitry

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Human research shows that D-allulose increases the release of gastrointestinal (GI) satiation hormones, such as GLP-1, peptide tyrosine tyrosine (PYY), and cholecystokinin (CCK).* 14 In a randomized, controlled, double-blind, crossover study, 18 participants received an intragastric administration of 25 grams D-allulose