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The pathogenesis and the pathophysiology of sepsis is very complicated and multifaceted: numerous biological mechanisms, such as infection, inflammation, oxidative stress, immune system dysregulation, blood coagulation, endothelium dysfunction, tissue damage, elevated cellular death and/or apoptosis are involved during sepsis at tissue, cellular and molecular levels causing a damaging systemic reaction [379]

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EGCG plays a vital role in Nrf2-related antioxidant activity

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Akbari M, Vali M, Rezaei S, Bazmi S, Tabrizi R, Lankarani KB