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Retatrutide vs Tirzepatide vs Semaglutide Three compounds dominate current GLP-1-class research conversation: semaglutide (single agonist), tirzepatide (dual agonist), and retatrutide (triple agonist) [3][4][9]

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Martin CMA, Irwin N, Flatt PR, Gault VA (2013) A novel acylated form of (d-Ala(2))GIP with improved antidiabetic potential, lacking effect on body fat stores