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Managing Common Side Effects Patients frequently complain of GI side effects while on semaglutide or tirzepatide: constipation, diarrhea, or just not wanting to eat at all
Diabetologia 13 , 537544 (1977)
Other growth hormone secretagogue peptides (CJC-1295, ipamorelin, MK-677) work through similar but not identical mechanisms
Beta-arrestin recruitment and receptor internalization vary between agonists at this receptor, and the relationship between internalization rate and sustained signaling is still argued
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