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What the clinical trial evidence shows Mounjaro (tirzepatide) ~22.5% average body weight lost at 72 weeks ( SURMOUNT-1, 15mg) Wegovy (semaglutide) ~14.9% average body weight lost at 68 weeks ( STEP-1 , 2.4mg) Saxenda / Nevolat (liraglutide) ~5-8% average body weight lost at 56 weeks ( SCALE trial ) For context, prior to GLP-1 medications, the most effective non-surgical weight loss intervention available was a combination of intensive lifestyle modification and Orlistat , which typically produces 5 to 8% weight loss
Gonadorelin and kisspeptin rank next because they sit upstream of LH and FSH signaling, but they are not simple over-the-counter testosterone boosters
Growth hormone response was 5065% lower than fasted pre-sleep dosing, not because the peptides were inactive, but because somatostatin tone and insulin interference blocked receptor signaling
For muscle growth and recovery, the combination addresses the full regenerative pathway
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