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In neuronal cells, IGF1 protects against prion diseases caused by mitochondrial dysfunction and increased ROS production via inhibition of Bax translocation (Park et al., 2012)

BAX, Bcl-X L , ERK1/2, Phospho-ERK (Thr980), SIRT3, BAD, cytochrome c and caspase-3 were separated by 10% sodium dodecyl sulfate polyacrylamide gel electrophoresis and later transferred to polyvinylidene fluoride (PVDF) membranes (EMD Millipore Corp., Billerica, MA, United States) in semi-dry transfer (trans-Blot SD, Bio-Rad, United States) and blocked for 4 h at room temperature

Initial research has found that Thymosin Beta 4 has anti-inflammatory properties and may boost heart health (35)