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The poly dopamine shell responds to a high ROS environment to release rutin, directly scavenging excess ROS within mitoROS, repairing disrupted ETC function, and stabilizing MMP, blocking abnormal opening of the mPTP and ferroptosis cascades, ultimately alleviating damage to renal tubular epithelial cells, significantly reducing serum LDH leakage, improving glomerular filtration function and histopathological damage, and achieving protective effects on IRI kidney function [57]

Sustained weight loss and reduction in visceral fat

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Testing may include SAM, SAH, methionine, homocysteine, whole-blood histamine, copper, zinc, ceruloplasmin, urinary pyrroles, organic acids, lactate, pyruvate, glutathione-related markers, 8-OHdG and lipid peroxides when clinically appropriate

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