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Remarkably, both OSKM and B 12 resulted in significantly improved tissue recovery on day 14, as evaluated by blinded histological analysis (Fig

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Microbiome differences were greater between the two groups switched from WD to LD (i.e., WD/LD-V and WD/LD-T) and the two diet control groups (i.e., LD/LD-V and WD/WD-V) compared to the microbiome differences observed between the lean (LD/LD-V) and obese (WD/WD-V) control groups

Combined use should always follow clinical assessment and should not replace investigation of underlying causes

Excess B12 is excreted through urine as a water-soluble vitamin, reducing the risk of toxicity