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Within the serotonergic alterations presented by patients with ME/CFS, it has been suggested that viral infection may cause damage to the bloodbrain barrier, leading to the entry of viral genetic material that activates TLR3 receptors in microglia, leading to increased release of IL-1 and TNF-, which increases SERT expression and activity in astrocytes and, therefore, increases 5-HT reuptake and its degradation to the metabolite 5-HIAA, thereby reducing extracellular levels of 5-HT [271, 285,286,287,288]
The key design elements are summarized in Extended Data Table 5 and detailed below
By completing your purchase, you acknowledge that DSIP (Delta Sleep-Inducing Peptide) is an investigational material not approved for general medical or therapeutic use by any regulatory authority
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