& Rinaldo, P
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Its goal is to even out pigmentation and enhance natural radiance, regardless of skin tone
Under oxidative stress and induced by excessive ROS generation, Nrf2 is released from its inhibitor Keap1, allowing its translocation into the nucleus (Kasprzak et al., 2020), where it binds to the antioxidant response element (ARE) present in the DNA sequence of numerous antioxidant enzymes like glutathione-S-transferase, -glutamyl cysteine synthetase (glutamate cysteine ligase), heme oxygenase 1, and paraoxonase-1 inducing their transcription, managing the phase II response to oxidative stress (Kasprzak et al., 2020)
reported rapid recovery in all the patients with HA who were on VPA monotherapy or combination therapy and presented with symptoms, after correction of blood ammonia with adjustment in the dose of VPA or lactulose treatment [9]