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Collectively, NAD + exerts its effects not through traditional receptor binding but through its indispensable role as a co-substrate and regulator of these enzymatic systems, which sense and respond to fluctuations in NAD + levels to coordinate cellular metabolism, survival, DNA repair, signaling, and cell fate decisions 1-4

Note: Hydroxocobalamin acetate belongs to the group of substances that are collectively referred to as "Vitamin B12"

[263] This enzyme was found to metabolize amphetamine, tyramine, and phenethylamine with roughly the same binding affinity for all three compounds

doi: 10.1038/nrneph.2015.215 71 HillsCESiamantourasESmithSWCockwellPLiuKKSquiresPE

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