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Yet, under regulation of the ISR pathway an ATF4-mediated upregulation of NRF2 via CHAC1 activity was shown as well ( 2.3.1 The dual role of CHAC1 in cancer CHAC1s function in cancer is complex and highly context-dependent

This concept is supported by our findings in obese Bbs5 / mice, which exhibit additional downregulation of Cck , Cckbr , Stat3 , and Socs3 expression, indicating that impaired leptin and CCK signaling contributes to the hyperphagia observed in BBS

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Sagara JI, Miura K, Bannai S