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This cell cycle blockade is concentration-dependent, with resveratrol-loaded AgNPs demonstrating enhanced apoptotic effects compared to free resveratrol through ROS-mediated DNA damage and caspase activation [70]

Current clinical trials and future studies should take into account gender-dependent factors, receptor polymorphism, and the selectivity of brain regions in order to optimize the translational potential of this strategy [114]

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Erzen, S., Tonin, G., Jurisic Erzen, D