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Teduglutide# Teduglutide is a 33-amino acid GLP-2 analog ([Gly2]-GLP-2) with a well-defined, single-target mechanism: GLP-2 receptor activation : Directly binds and activates the GLP-2 receptor on intestinal subepithelial myofibroblasts IGF-1 stimulation : GLP-2R activation stimulates production of insulin-like growth factor 1 in the intestinal wall Crypt cell proliferation : IGF-1 drives proliferation of intestinal crypt cells, expanding the stem cell compartment Villus growth : Increased crypt cell production leads to villus elongation and greater absorptive surface area Intestinal adaptation : The combined effect promotes structural adaptation of the remaining bowel in SBS patients Mechanistic Comparison# Dosing Comparison# BPC-157 Dosing# Teduglutide Dosing# Side Effects Comparison# BPC-157 Side Effects# No systematic human safety data exists