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We showed that GDH1 knockdown significantly reduces intracellular -KG abundance in several liver and lung cancer cell lines and GDH1 knockdown also reduces -KG levels in certain breast cancer cells (MDA-MB231), HEL and K562 leukemia cells and brain tumor cells 19,21

If delivery can be demonstrated alongside biological activity, the case for rigorous wound healing trials strengthens considerably

This ammonia-scavenging role is particularly vital for helping to prevent neurotoxicity and reducing the muscular fatigue that often accompanies elevated ammonia levels

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