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Also, xenografts study results showed smaller cancer nodules and fewer incidences of lung metastases in LV-miR-489-3p group compared with LV-control group, indicating the apparent inhibition of OS metastasis in vivo (Liu Q

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In these mechanisms of PGs, LTs, LXs, PAF, receptors play significant roles, therefore inhibitors or agonists of these receptors can exert therapeutic functions, and the therapeutic effects are proven in animal experiments ( Figure 3 )