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Clinical trials and recent meta-analyses consistently show tirzepatide delivers the most substantial weight reduction among GLP-1 medications, with average losses of up to 22.5% of body weight

Long-Term Effects: Benefits like improved skin tone, reduced inflammation, and enhanced immune function typically require consistent treatments over several weeks or months

Differences come down to dose and delivery method: Wondering how semaglutide stacks up against Tirzepatide for side-effect profile and weight-loss outcomes

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Padhi et al., 2024)