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Glucagon receptor activation likely requires threshold concentrations

So in the pancreas, we know that it's primarily on the insulin producing cells, and then we also have them in the intestine where they're probably involved in regulating inflammation and really creating a much healthier gut

The oral vs injection comparison shows that efficacy appears similar in clinical studies, though oral formulations have their own considerations including specific fasting requirements and potentially different GI side effect profiles

Ultimately, a precision medicine approach will be essential in navigating this multifaceted condition and improving patient care in MASH management

GLP-1RAs, which achieved great success in 2023 and draws peoples attention back to obesity treatments and GLP-1 therapies worldwide, was chosen as the breakthrough of year 2023 by Science [2]