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SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism

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Clinically significant weight loss of at least 5% was achieved by 89% and 91% of participants, while 6771% lost at least 15% of their body weight

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Among enrolled patients, the mean bodyweight was 99.8 kg (standard deviation [SD] 21.5) and the mean BMI was 35.7 kg/m 2 (SD 6.3)