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Onset pattern: Published data indicates most GI events occurred during the dose-escalation phase and diminished over time as participants continued at stable doses

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We used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) classification for assessment of the certainty of the evidence

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NEJM 2023: 10.1056/NEJMoa2301972 Phase 2 dose-response (1, 4, 8, 12 mg arms, 48 wk, non-diabetic obesity)

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Together, they provide a foundation for sharper thinking and steadier emotional balance

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