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Notably, similar inhibitions were observed both with the wild type enzyme and its cysteine mutants, suggesting that thiol conjugation is dispensable for GST inactivation by auronofin in contrast to other described targets 103

inhibition of DHFR sensitizes cells to ferroptosis (Wang et al., 2024)

Supplementing with a bioavailable form is a common way to bridge that gap.

Amino Acids 32:225233 Hipkiss AR, Brownson C (2000) A possible new role for the anti-ageing peptide carnosine

GLS, one of the key enzymes in this pathway, is upregulated in various tumors and is thus considered a potential therapeutic target for cancer